Search results for "genetics [Transcriptome]"

showing 10 items of 3033 documents

Endocrine therapy of breast cancer. The experience of the Italian Cooperative Group for Chemohormonal Therapy of Early Breast Cancer (GROCTA).

1993

Oncologymedicine.medical_specialtybusiness.industryGeneral NeuroscienceEndocrine therapyBreast Neoplasmsmedicine.diseaseGeneral Biochemistry Genetics and Molecular BiologyPostmenopauseTamoxifenBreast cancerHistory and Philosophy of SciencePremenopauseReceptors EstrogenChemotherapy AdjuvantRecurrenceInternal medicinemedicineCooperative groupHumansFemalebusinessEarly breast cancerProbability
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 Consistency and Proportionality in Policy Decision-Making in Blood Safety: the Case for an All-Apheresis Platelet Supply in Germany

2013

SUMMARY Recently, German investigators presented the first mathematical model finding a significant increase in the risk of HIV, HCV, and HBV transmission when pools of 4 whole-blood-derived buffy-coat platelets, rather than 1 singledonor (apheresis) component, are used to provide one platelet dose. Based, in both cases, on mathematical models employing the incidence/window-period method, the relative risk of transmission from pooled versus apheresis platelets (2.2 or 2.75 for HIV, 2.7 or 3.375 for HCV, and 3.2 or 4.0 for HBV, with pools of 4 or 5 concentrates, respectively) is similar to the difference in risk before (versus after) introduction of HIV-1 and HCV RNA screening. The absolute …

Oncologymedicine.medical_specialtybusiness.industryHuman immunodeficiency virus (HIV)Viral transmissionvirus diseasesPathogen reductionmedicine.disease_causeGeneral Biochemistry Genetics and Molecular BiologyPolicy decisionInternal medicineRelative riskImmunologymedicineBlood safetyPlateletbusinessModel findingClinical Laboratory
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Evaluation of atezolizumab immunogenicity: Efficacy and safety (Part 2).

2022

Abstract Antibody therapeutics can be associated with unwanted immune responses resulting in the development of anti‐drug antibodies (ADA). Optimal methods to evaluate the potential effects of ADA on clinical outcomes in oncology are not well established. In this study, we assessed efficacy and safety, based on ADA status, in patients from over 10 clinical trials that evaluated the immune checkpoint inhibitor atezolizumab as a single agent or as combination therapy for several types of advanced cancers. ADA can only be observed post randomization, and imbalances in baseline prognostic factors can confound the interpretation of ADA impact. We applied methodology to account for the confoundin…

Oncologymedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesRandomizationCombination therapyDatabases FactualMEDLINERM1-950Antibodies Monoclonal HumanizedGeneral Biochemistry Genetics and Molecular BiologyArticleAtezolizumabimmune system diseasesInternal medicineNeoplasmsmedicineHumansGeneral Pharmacology Toxicology and PharmaceuticsAdverse effectImmune Checkpoint InhibitorsClinical Trials as Topicbusiness.industryGeneral NeuroscienceImmunogenicityResearchConfoundingnutritional and metabolic diseaseshemic and immune systemsGeneral MedicineArticlesAntibodies Monoclonal Humanized/immunology; Antibodies Monoclonal Humanized/pharmacokinetics; Antibodies Neutralizing/immunology; Antibodies Neutralizing/metabolism; Clinical Trials as Topic; Databases Factual; Humans; Immune Checkpoint Inhibitors/immunology; Immune Checkpoint Inhibitors/pharmacokinetics; Neoplasms/drug therapy; Safety; Treatment OutcomeAntibodies NeutralizingClinical trialenzymes and coenzymes (carbohydrates)Treatment OutcomeTherapeutics. PharmacologyPublic aspects of medicineRA1-1270SafetybusinessClinical and translational science
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Estrogen content and metabolism in human breast tumor tissues and cells.

1996

Oncologymedicine.medical_specialtymedicine.drug_classbusiness.industryGeneral NeuroscienceEstrogen receptorTumor cellsBreast NeoplasmsEstrogensMetabolismTumor tissueGeneral Biochemistry Genetics and Molecular BiologyText miningHistory and Philosophy of ScienceEstrogenInternal medicinemedicineCancer researchTumor Cells CulturedHumansFemalebusinessHuman breastAnnals of the New York Academy of Sciences
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CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review

2021

Patients with postransplant lymphoproliferative disease (PTLD) who are refractory to rituximab-based regimens have extremely poor prognosis. Data is lacking in the setting of solid organ transplantation (SOT)-related PTLD treated with chimeric antigen receptor T-cell (CAR-T) therapy. Moreover, limited information is available on the influence of concomitant immunosuppressive drugs on CAR-T function. Here, we describe the clinical outcome in one PTLD patient and propose a strategy for tailoring immunosuppressive treatment and organ monitoring in patients with kidney allografts after CAR-T infusion. This report also reviews the limited published data in the setting of SOT-related PTLD treated…

Oncologymedicine.medical_specialtymedicine.medical_treatmentImmunotherapy AdoptiveGeneral Biochemistry Genetics and Molecular BiologyRefractoryhemic and lymphatic diseasesInternal medicinemedicineHumansKidneyReceptors Chimeric Antigenbusiness.industryImmunosuppressionOrgan TransplantationGeneral MedicineLymphoproliferative DisordersTransplant RecipientsChimeric antigen receptorDiscontinuationsurgical procedures operativemedicine.anatomical_structureConcomitantRituximabLymphoproliferative diseasebusinessmedicine.drugCurrent Research in Translational Medicine
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Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study

2012

Item does not contain fulltext INTRODUCTION: A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Caucasian ancestry. METHODS: 4389 SSc patients and 7611 healthy controls from different European countries and the USA were included in the study. Six single nucleotide polymorphisms (SNP): rs342070, rs13021401 (RHOB), rs2233287, rs4958881, rs3792783 (TNIP1) and rs3130573 (PSORS1C1) were analysed. Overall significance was calculated by pooled analys…

Oncologymedicine.medical_specialtysystemic sclerosisRHOBImmunologyGenome-wide association studySingle-nucleotide polymorphismBioinformaticsPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyArticleWhite PeopleRheumatologyRisk FactorsInternal medicineRhoB GTP-Binding Proteinsystemic sclerosis; genome wide screening; genetic risk factorsmedicinegenetic risk factorsImmunology and AllergySNPHumansGenetic Predisposition to DiseaseAllelerhoB GTP-Binding ProteinRheumatology and AutoimmunityScleroderma Systemicbusiness.industryHaplotypeProteinsgenome wide screeningDNA-Binding ProteinsEuropeHaplotypesCohortEvaluation of complex medical interventions Auto-immunity transplantation and immunotherapy [NCEBP 2]businessGenome-Wide Association Study
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Engineering Bacteria to Form a Biofilm and Induce Clumping in Caenorhabditis elegans

2014

Bacteria are needed for a vast range of biotechnological processes, which they carry out either as pure cultures or in association with other bacteria and/or fungi. The potential of bacteria as biofactories is hampered, though, by their limited mobility in solid or semisolid media such as agricultural or domestic waste. This work represents an attempt toward overcoming this limitation by associating bacterial biotechnological properties with the transport ability of the nematode Caenorhabditis elegans. We report here biofilm formation on C. elegans by engineered Escherichia coli expressing a Xhenorhabdus nematophila adhesion operon and induction of nematode social feeding behavior (clumping…

OperonBiomedical EngineeringBioengineeringBiologymedicine.disease_causeBiochemistry Genetics and Molecular Biology (miscellaneous)Biotechnological processMicrobiologyRNA interferenceEscherichia colimedicineAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsSymbiosisEscherichia coliCaenorhabditis elegansBiofilmFeeding BehaviorGeneral Medicinebiology.organism_classificationNematodeBiofilmsRNA InterferenceSynthetic BiologyBacteriaACS Synthetic Biology
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Evaluating plasmonic transport in current-carrying silver nanowires

2013

cited By 1; International audience; Plasmonics is an emerging technology capable of simultaneously transporting a plasmonic signal and an electronic signal on the same information support1,2,3. In this context, metal nanowires are especially desirable for realizing dense routing networks4. A prerequisite to operate such shared nanowire-based platform relies on our ability to electrically contact individual metal nanowires and efficiently excite surface plasmon polaritons5 in this information support. In this article, we describe a protocol to bring electrical terminals to chemically-synthesized silver nanowires6 randomly distributed on a glass substrate7. The positions of the nanowire ends …

Optics and PhotonicsSilverMaterials scienceGeneral Chemical EngineeringNanowireMetal Nanoparticles02 engineering and technology010402 general chemistry[ CHIM ] Chemical Sciences01 natural sciencesGeneral Biochemistry Genetics and Molecular Biology[CHIM]Chemical SciencesSurface plasmon resonancePlasmonGeneral Immunology and MicrobiologyNanowiresbusiness.industryPhysicsGeneral NeuroscienceSurface plasmonElectric ConductivityPlasmonic CircuitrySurface Plasmon Resonance021001 nanoscience & nanotechnology0104 chemical sciencesNanolithographyResistOptoelectronics0210 nano-technologybusinessLocalized surface plasmon
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Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Rando…

2015

Although older people are particularly liable to sarcopenia, limited research is available on beta-hydroxy-beta-methylbutyrate (HMB) supplementation in this population, particularly in healthy subjects. In this parallel-group, randomized, controlled, open-label trial, we aimed to evaluate whether an oral supplement containing 1.5 g of calcium HMB for 8 weeks could improve physical performance and muscle strength parameters in a group of community-dwelling healthy older women. Eighty healthy women attending a twice-weekly mild fitness program were divided into two equal groups of 40, and 32 of the treated women and 33 control completed the study. We considered a change in the Short Physical …

OralGenetics and Molecular Biology (all)medicine.medical_specialtyAbsorptiometry Photon; Administration Oral; Aged; Aged 80 and over; Female; Humans; Valerates; Dietary Supplements; Hand Strength; Physical Fitness; Agricultural and Biological Sciences (all); Biochemistry Genetics and Molecular Biology (all); Medicine (all)Strength trainingPopulationPhysical fitnessAdministration Orallcsh:MedicineIsometric exerciseBiochemistrynot knownlaw.inventionAbsorptiometry PhotonRandomized controlled triallawHand strength80 and overValeratesmedicineHumansAbsorptiometrylcsh:ScienceeducationAgedAged 80 and overGeriatricseducation.field_of_studyMultidisciplinaryHand Strengthbusiness.industryMedicine (all)lcsh:Rmedicine.diseasePhotonAgricultural and Biological Sciences (all)Physical FitnessSarcopeniaAdministrationDietary SupplementsPhysical therapyFemalelcsh:Qbusinesshuman activitiesResearch ArticlePLOS ONE
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The chemical composition of the floral extract of Epipogium Aphyllum sw. (Orchidaceae): A cluefor thier pollination biology

2014

Epipogium aphyllum is a rare European obligate mycoheterotrophic orchid lacking chlorophyll. It has not been studied previously with respect to pollination biology. We studied the association between the composition of floral scent emission and its pollination systems. Field observation indicates that the main pollinators of Epipogium aphyllum are representatives of the genus Bombus (Hymenoptera), B. lucorum, B. hortorum, B. terrestris, B. pascuorum and B. proteus, and the genus Apis (Hymenoptera) namely A. mellifera. The main potential vector (observed to accidentally carry pollen), is most likely Episyrphus balteatus (Diptera, Syrphidae). The chemical composition of the floral extracts of…

OrchidaceaeMethyl cinnamatebiologyPollinationNonacosanebiology.organism_classificationmedicine.disease_causeEpipogium aphyllumGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundlcsh:Biology (General)chemistryEpipogium aphyllumPollinatorPollenEpisyrphus balteatusBotanymedicineGeneral Agricultural and Biological Scienceslcsh:QH301-705.5floral extractpollination strategyArchives of Biological Sciences
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